Abstract #0358
Layer-Dependent Calibrated BOLD Response in Human M1
Maria Guidi 1 , Laurentius Huber 1 , Leonie Lampe 1 , Claudine J. Gauthier 1 , and Harald E. Mller 1
1
Max Planck Institute for Human Cognitive and
Brain Sciences, Leipzig, Germany
The Davis model for blood oxygenation level dependent
(BOLD) signal changes gives the possibility of
estimating cerebral metabolic rate of oxygen consumption
(CMRO2) changes noninvasively. The increased resolution
offered by ultra-high fields (7T) paved the way for
layer dependent studies and for the investigation of
CMRO2 distribution across cortical layers. Scaled BOLD
and vascular space occupancy (VASO) profiles, together
with M and CMRO2 estimates in human primary motor
cortex, were obtained at high resolution (0.8x0.8x1.5
mm3) and showed a marked change with cortical depth,
implying that the assumption of constant values across
the cortex should be decisively called into question.
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