Evaluating a Semi-continuous Multi-compartmental Intra-Voxel Incoherent Motion (IVIM) Model in the Brain: How Does the Method Influence the Results in IVIM?

A restriction to the clinical application of intravoxel-incoherent motion (IVIM) "microperfusion" MRI in the brain is the ill-posed problem to deconvolute the multi-exponential process of water diffusion. We compared mono- and bi-exponential fitting methods with a recently established semi-continuous multi-exponential non-negative least squares function diffusion model (32 b-values, 0 - 2000 s/mm) and T1-weighted dynamic contrast-enhanced MRI in 30 patients and 9 healthy controls. Perfusion fractions and ADC values varied significantly between all approaches and were not comparable to results of T1-DCE MRI. This study discusses possible effects of fitting choice to be considered when appIying IVIM in the CNS.n. We compared mono- and bi-exponential fitting methods with results of a recently established semi-continuous multi-exponential non-negative least squares function diffusion model (32 b-values, 0 - 2000 s/mm) and T1-weighted dynamic contrast-enhanced MRI in 30 patients and 9 healthy controls. Perfusion fractions vPF and ADC values varied significantly between all approaches and were not comparable to results of T1-DCE MRI. This study discusses possible effects of fitting choice to be considered using IVIM in the CNS.

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