Abstract #0344
In vivo and ex vivo Characterization of Extracellular Space (ECS) in mouse GBM using PGSE and OGSE
Olivier Reynaud 1,2 , Kerryanne V Winters 1,2 , Dung Minh Hoang 1,2 , Youssef Zaim Wadghiri 1,2 , Dmitry S Novikov 1,2 , and Sungheon Gene Kim 1,2
1
Center for Advanced Imaging Innovation and
Research (CAI2R), Department of Radiology, New York
University School of Medicine, New York, NY, United
States,
2
Bernard
and Irene Schwartz Center for Biomedical Imaging,
Department of Radiology, New York University School of
Medicine, New York, NY, United States
In this study, we combine OGSE and PGSE measurements to
probe the short diffusion time ([1.2-30]ms) dependence
of ADC in a GBM. Based on tumor microenvironment
modeling, parametric maps of Extracellular Space (ECS),
Cell Radius and ECS free diffusivity are derived,
showing high ECS heterogeneity inside the tumor and
positive correlation of ECS with PGSE-ADC at long
diffusion times. Fitting on ex vivo ADC measurements
performed with a MR microcoil on 100um thick fixed brain
slices are compared to cellular membrane immuno-staining
(GLUT1) to validate ECS quantification. Regions of
high/low ECS correlate with regions of low/high cell
volume fraction.
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