Abstract #0336
In vivo Assessment of Cold Stimulation Effects on the Fat Fraction of Brown Adipose Tissue using Dixon MRI
Vanessa Stahl 1 , Florian Maier 1 , Ralf O. Floca 2 , Moritz C. Berger 1 , Mauricio Berriel Diaz 3 , Martin T. Freitag 2 , Marc-Andr Weber 4 , Antonia Dimitrakopoulou-Strauss 5 , and Armin M. Nagel 1
1
Medical Physics in Radiology, German Cancer
Research Center, Heidelberg, Germany,
2
Department
of Radiology, German Cancer Research Center, Heidelberg,
Germany,
3
Molecular
Metabolic Control, German Cancer Research Center,
Heidelberg, Germany,
4
Diagnostic
and Interventional Radiology, University Hospital of
Heidelberg, Heidelberg, Germany,
5
Clinical
Cooperation Unit Nuclear Medicine, German Cancer
Research Center, Heidelberg, Germany
Brown adipose tissue (BAT) is subject of ongoing
research because of its ability to dissipate energy
through non-shivering thermogenesis giving therapeutic
potential for the treatment of obesity and metabolic
diseases in humans. The purpose of this work was to
evaluate in vivo the acute activation of BAT by induced
cooling of the skin using Dixon water-fat-separated MRI.
The fat fraction (FF) of BAT was determined over time in
five volunteers in a temperature-controlled measurement
including 90 minutes of cooling time. Focusing on the
two interscapular BAT depots, a mean FF decrease of
(-4.0 1.7) % / h was detected and therefore FF changes
over time in BAT during cooling could be observed.
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