Abstract #0325
Effect of Epinephrine on Metabolism of HP [1- 13 C]pyruvate in Low-flow Myocardial Ischemia
Chalermchai Khemtong 1 , Wei Chen 1 , Weina Jiang 1 , Craig R Malloy 1,2 , and A. Dean Sherry 1,3
1
Advanced Imaging Research Center, University
of Texas Southwestern Medical Center, Dallas, TX, United
States,
2
Veterans
Affairs North Texas Health Care System, Dallas, TX,
United States,
3
Chemistry,
University of Texas at Dallas, Richardson, TX, United
States
Adrenergic agents are widely used to assess cardiac
conditions. Hyperpolarized (HP)
13
C-MRS
offers direct assessment of metabolic consequences of
adrenergic stimulation rather than assessing metabolism
based on mechanical function. We tested whether
metabolism of HP-[1-
13
C]pyruvate is sensitive
to adrenergic stimulation or ischemia in perfused
hearts. During normal perfusion conditions, epinephrine
increased glycolysis and glycogenolysis to lactate, and
production of HP-bicarbonate from [1-
13
C]pyruvate.
During ischemia, epinephrine had little effect on the
HP-signals after HP-[1-
13
C]pyruvate, because
coronary flow could not increase. HP-pyruvate is
preferentially converted to alanine rather than lactate
during ischemia after epinephrine, indicating
compartmentation of HP-pyruvate metabolism in ischemic
heart.
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