Abstract #0323
Application of Goods buffers to pH imaging using hyperpolarized 13C-MRI
Robert R Flavell 1 , David Korenchan 1 , Cornelius von Morze 1 , Mark Van Criekinge 1 , Renuka Sriram 1 , Sukumar Subramaniam 1 , Robert Bok 1 , Joseph Blecha 1 , Daniel Vigneron 1 , Peder Larson 1 , Kayvan R Keshari 2 , John Kurhanewicz 1 , and David M Wilson 1
1
Radiology and biomedical imaging, University
of California, San Francisco, San Francisco, CA, United
States,
2
Memorial
Sloan-Kettering Cancer Center, New York, NY, United
States
Solid tumors have numerous mechanisms to export acid
into the extracellular space, resulting in a low
interstitial pH. In this abstract we report a novel
method for imaging this property using hyperpolarized
13C,15N ACES, a commonly used biological buffer. ACES
demonstrates remarkable pH dependent chemical shift
change over the physiologic range. Application to
phantom imaging and preliminary in vivo imaging
experiments will be presented. This method combines the
large 13C chemical shifts of HP ACES in the physiologic
range, with the dramatic signal enhancements afforded by
dissolution dynamic nuclear polarization (DNP).
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