Abstract #0266
Wedge-shaped slice-selective adiabatic inversion pulse for bolus temporal width control in pulsed arterial spin labeling
Jia Guo 1 , Richard B. Buxton 1 , and Eric C. Wong 1,2
1
Radiology, UC San Diego, La Jolla,
California, United States,
2
Psychiatry,
UC San Diego, La Jolla, California, United States
The Turbo-QUASAR strategy proposed by Petersen and
colleagues to improve the temporal signal-to-noise
(tSNR) of arterial spin labeling (ASL) experiments works
optimally when the temporal width of the tagged boluses
matches the inter-pulse spacing. However, this cannot be
accomplished using a conventional labeling slab because
the feeding arteries will generally have different
velocities and geometries. In order to remedy this, we
propose a novel labeling strategy by creating a
wedge-shaped (WS) inversion slab using additional
in-plane gradients with minimal reduction in its
adiabaticity. The WS inversion pulse may potentially be
used to control and match the bolus temporal width in
different feeding arteries, maximizing the tSNR in fast
Pulsed ASL measurements.
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