Abstract #0232
Differentiation of Early-Stage Parkinsonisms with Diffusion Kurtosis Imaging Using The Diffusion Magnetic Resonance Parkinsonism Index
Kenji Ito 1 , Makoto Sasaki 1 , Chigumi Ohtuka 2 , Suguru Yokosawa 3 , Taisuke Harada 1 , Ikuko Uwano 1 , Fumio Yamashita 1 , Satomi Higuchi 1 , and Yasuo Terayama 2
1
Division of Ultrahigh Field MRI, Institute
for Biomedical Sciences, Iwate Medical University,
Yahaba, Iwate, Japan,
2
Department
of Neurology and Gerontology, Iwate Medical University,
Morioka, Iwate, Japan,
3
Central
Research Laboratory, Hitachi, Ltd., Kokubunji, Tokyo,
Japan
The differential diagnosis of early-stage parkinsonisms,
such as Parkinsonfs disease, multiple system atrophy,
and progressive supranuclear palsy is often difficult.
Hence, we investigated whether diffusion kurtosis
imaging (DKI) with a quantitative imaging marker, the
diffusion magnetic resonance parkinsonism index (dMRPI),
can help to differentiate between these disorders. The
dMRPI of mean kurtosis (MK) differed significantly among
the patients compared to the dMRPI of fractional
anisotropy/mean diffusivity, conventional MRPI, and
123I-metaiodobenzylguanidine scintigraphy. The
sensitivities and specificities of dMRPI-MK for the
differentiations were both over 80%. This quantitative
index can therefore contribute to early differential
diagnoses of neurodegenerative disorders showing
parkinsonism.
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