Abstract #0228
Effect of oxygen challenge on MR imaging of tumor microenvironment
Zhongwei Zhang 1 , Qing Yuan 1 , Heling Zhou 1 , and Ralph P Mason 1
1
Department of Radiology, UT Southwestern
Medical Center, Dallas, TX, United States
Few studies have been performed to reveal the changes of
tumor microenvironment such as diffusion and perfusion
parameters in response to oxygen challenge. The purpose
of this study was to evaluate the effect of oxygen
challenge on tumor heterogeneity, diffusion and
perfusion parameters at the microscopic level. The
current study demonstrated that IVIM diffusion MRI
provided powerful insight into tumor perfusion. On the
other hand, diffusion stretched-exponential model was
sensitive to the changes of tumor heterogeneity,
Combining these two models may serve as potential
biomarker to evaluate tumor responses to oxygen.
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