Abstract #0224
Iron-Oxide Driven Decrease in T2 Relaxation Times Correlates with Tumor Associated Macrophages (TAMs) in Postpartum Pregnancy Associated Breast Cancer Xenografts
J C Montejano 1 , K M Huber 1 , V F Borges 1 , P J Schedin 2 , and N J Serkova 1
1
University of Colorado Anschutz Medical
Campus, Aurora, Colorado, United States,
2
Oregon
Health and Science University, Oregon, United States
In this study, superparamagnetic iron nanoparticles
(SPION) were used as a contrast agent for the imaging of
macrophage driven inflammation in postpartum pregnancy
associated breast cancer (PPABC) by T2-MRI. A cohort of
immunocompetent BALB/C mice were injected with a murine
breast cancer cell line and injected with SPION contrast
24 hours prior to imaging. When compared to virgin
counterparts, postpartum mice showed a large decrease in
T2 relaxation times. This study has shown that SPIONs
are an appropriate contrast agent for the assessment of
the TAM-rich tumor microenvironment in PPABC.
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