Abstract #0219
A streamlined approach to mapping the oxygen extraction fraction (OEF) and deoxygenated blood volume (DBV) using the quantitative BOLD technique
Alan J Stone 1 and Nicholas P Blockley 1
1
FMRIB, Nuffield Department of Clinical
Neurosciences, Oxford, United Kingdom
There is a need for an easy-to-implement MR method
capable of providing quantitative parametric maps of OEF
and DBV across the brain in a clinically feasible
timescale. In this study a FLAIR GESEPI ASE sequence is
used to provide a refined measure of R
2
′
through optimisation of the data acquisition. The
components of the sequence are selected to minimise
confounds associated with CSF partial volume effects
(FLAIR), macroscopic field inhomogeneities (GESEPI) and
R
2
-weighting (ASE) of the R
2
′
signal. This affords a simplified application of the
qBOLD signal model, allowing parametric maps of OEF and
DBV to be produced in a streamlined process.
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