Abstract #0214
The impact of normoxic and hyperoxic baseline periods in block paradigms of hypercarbic cerebrovascular reactivity studies
Carlos C. Faraco 1 , Jeroen C.W. Siero 2 , Megan K. Strother 1 , Daniel F. Arteaga 1 , and Manus J. Donahue 1
1
Radiology and Radiological Sciences,
Vanderbilt University School of Medicine, Nashville, TN,
United States,
2
Department
of Radiology, University Medical Center Utrecht,
Utrecht, Netherlands
Identification of cerebrovascular compromise in the
clinic is frequently performed using catheter
angiography, which is insensitive to tissue-level
hemodynamics and is sub-optimal for longitudinal
monitoring. Alternatively, hypercarbic-normoxic BOLD
fMRI may be used to assess cerebrovascular reactivity
(CVR). As a significant proportion of patients for whom
CVR assessment is desirable are hypoxic, and may be
operating near reserve capacity, hypercarbic-hyperoxic
(HC-HO) BOLD fMRI is advisable. However, HC-HO stimuli
introduce several experimental confounds, including
non-specific venous O2 rebinding to dHb. Here we
demonstrate that administration of baseline HO, before
HC-HO, resolves or reduces the drawbacks associated with
HC-HO CVR-weighted BOLD imaging.
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