Abstract #0170
Longitudinal characterization of brain microstructure and visuomotor behavior following acute ocular hypertension using diffusion tensor imaging, magnetization transfer imaging and optokinetics
Yolandi van der Merwe 1,2 , Leon C. Ho 1,3 , Xiaoling Yang 1,4 , Michael B. Steketee 4 , Seong-Gi Kim 1,5 , Gadi Wollstein 4 , Joel S. Schuman 2,4 , and Kevin C. Chan 1,4
1
Neuroimaging Laboratory, University of
Pittsburgh, Pittsburgh, Pennsylvania, United States,
2
Department
of Bioengineering, Swanson School of Engineering,
University of Pittsburgh, Pittsburgh, Pennsylvania,
United States,
3
Department
of Electrical and Electronic Engineering, University of
Hong Kong, Pokfulam, Hong Kong, China,
4
Department
of Ophthalmology, School of Medicine, University of
Pittsburgh, Pittsburgh, Pennsylvania, United States,
5
Center
for Neuroscience Imaging Research, Institute for Basic
Science, Sungkyunkwan University, Suwon, Korea
An increase in intraocular pressure (IOP) is often
associated with vision-related diseases like glaucoma
and retinal ischemia, and cardiovascular diseases such
as stroke. There exists a need to understand what
happens in the visual pathway regarding function,
structural integrity, and metabolic activity as these
diseases progress. Here we used a model of ocular
hypertension (OHT) induction to mimic the effects on the
visual system observed in IOP increased
neurodegenerative diseases. Diffusion tensor imaging,
magnetization transfer imaging, and optokinetics were
employed to longitudinally analyze the microstructural
integrity and visuomotor behavior following OHT to help
understand the disease mechanisms associated with
elevated IOP.
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