Abstract #0164
A multi-parametric investigation of vascular alterations in elderly with hypertension
Min Sheng 1 , Kevin S. King 2 , Adam Sheffield 3 , Harshan Ravi 1 , Shin-Lei Peng 1 , Peiying Liu 1 , Zohre German 4 , and Hanzhang Lu 1
1
Advanced Imaging Research Center, University
of Texas Southwestern Medical Center, Dallas, Texas,
United States,
2
Department
of Radiology, University of Texas Southwestern Medical
Center, Dallas, Texas, United States,
3
Medical
program, University of Texas Southwestern Medical
Center, Dallas, Texas, United States,
4
Department
of Neurology, University of Texas Southwestern Medical
Center, Dallas, Texas, United States
Hypertension is a major risk factor for stroke,
dementia, and cognitive decline. In order to investigate
more sensitive biomarker of vascular dysfunction in the
brain, we conducted a multiparametric investigation of
hemodynamic changes in hypertension, including cerebral
blood flow (CBF), venous cerebral blood volume (vCBV),
venous oxygenation (Yv), and cerebrovascular reactivity
(CVR) to CO2. In this study, we found that CBF and Yv
increased with blood pressure while CVR decreased with
blood pressure in elderly subjects. vCBV did not show
any difference in hypertension. These vascular markers
may precede structural changes of the brain and clinical
symptoms.
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