Abstract #0156
Estimating microstructural properties of a biomimetic tumour tissue phantom using diffusion-weighted MRI
Damien J McHugh 1,2 , Fenglei Zhou 1,3 , Penny L Hubbard Cristinacce 1,2 , Josephine H Naish 1,2 , and Geoff J M Parker 1,2
1
Centre for Imaging Sciences, The University
of Manchester, Manchester, United Kingdom,
2
Biomedical
Imaging Institute, The University of Manchester,
Manchester, United Kingdom,
3
Materials
Science Centre, The University of Manchester,
Manchester, United Kingdom
In this work we introduce a novel phantom with
microstructural characteristics mimicking tumour
cellular structure, consisting of a collection of
roughly spherical polymer structures. A two-compartment
biophysical model was applied to diffusion data acquired
over a range of gradient strengths and diffusion times,
allowing the size and volume fraction of the cells to
be estimated. The radius was slightly underestimated
compared with that determined from scanning electron
microscope measurements, the fitted volume fraction was
plausible, and parameters were found to be estimated
with reasonably good precision. Such phantoms may be
useful for testing microstructural models of the
diffusion signal, and for scanner and protocol
calibration.
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