Abstract #0095
Hyperpolarized Metabolic MR Imaging of Acute Myocardial Changes and Recovery Upon Ischemia-Reperfusion
Patrick Wespi 1 , Darach O h-Ici 1,2 , Julia Busch 1 , Lukas Wissmann 1 , Marcin Krajewski 1 , Kilian Weiss 1 , Andreas Sigfridsson 1 , Daniel Messroghli 2 , and Sebastian Kozerke 1,3
1
Institute for Biomedical Engineering,
University and ETH Zurich, Zurich, Switzerland,
2
Department
of Congenital Heart Disease and Pediatric Cardiology,
German Heart Institute, Berlin, Germany,
3
Division
of Imaging Sciences and Biomedical Engineering, King's
College London, London, United Kingdom
The aim of the present work was to study in vivo the
metabolic changes following left coronary artery
occlusion. Rats were scanned using hyperpolarized
[1-13C] pyruvate before coronary occlusion and directly
after reopening of the coronary artery after 15 minutes
of ischemia. Scans were repeated throughout the first
hour of reperfusion, and then at 1 week following
coronary occlusion. Data were correlated to local
regional function using cine imaging and to myocardial
injury based on late gadolinium enhancement (LGE)
imaging. Myocardial metabolism was abnormal in the
area-at-risk during the first 60 minutes following
ischemia, but returned to normal one week later.
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