Abstract #0085
Systematic comparison between modified Dixon MRI techniques, MR spectroscopic relaxometry, and different histologic quantification methods in the assessment of fatty liver disease
Guido Matthias Kukuk 1 , Alois Martin Sprinkart 1 , Wolfgang Block 1 , Holger Eggers 2 , Jrgen Gieseke 1,3 , Kanishka Hittatiya 1 , Patrick Kupczyk 1 , Julian Luetkens 1 , Rami Homsi 1 , Vera Keil 1 , Michael Meier-Schroers 1 , Milka Marinova 1 , Asadeh Lakghomi 1 , Dariusch Hadizadeh 1 , Hans Heinz Schild 1 , and Frank Trber 1
1
University of Bonn, Bonn, NRW, Germany,
2
Philips
Research Europe, Hamburg, Hamburg, Germany,
3
Philips
Healthcare, Best, NL, Netherlands
The availability of various non-invasive and invasive
techniques for liver fat quantification raises the
question for comparability and congruence of
quantitative results. Therefore we performed a
systematic comparison of mDixon MRI techniques, MRS and
two different histologic methods for liver fat
quantification. Our results demonstrate that six-echo-mDixon,
MRS and semi-automatic histologic fat quantification
provide the most robust and congruent data. The
performance characteristics and systematic differences
of the various fat quantification methods should be
considered in clinical routine and in further studies
when comparing results obtained from biopsy with
quantitative MRI or MRS.
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