Abstract #0073
Abnormal Tumor and Peritumor Vasculature and Metabolism Differentiate Primary from Metastatic Brain Tumors
Ingrid Digernes 1 , Frdric Courivaud 1 , Cathrine Saxhaug 2 , Marco C. Pinho 3 , Oliver M. Geier 1 , Einar Vik-Mo 4 , Knut Haakon Hole 5 , Grete Lovland 1 , Svein Are Vatnehol 1 , Torstein R. Meling 4 , Otto Rapalino 6 , Atle Bjornerud 1,7 , and Kyrre E. Emblem 1
1
The Intervention Centre, Oslo University
Hospital, Oslo, Oslo, Norway,
2
Department
of Radiology, Oslo University Hospital, Oslo, Norway,
3
Department
of Radiology, University of Texas Southwestern Medical
Center, Dallas, TX 75235, United States,
4
Department
of Neurosurgery, Oslo University Hospital, Oslo, Norway,
5
Departement
of Radiology, Oslo University Hospital, Oslo, Norway,
6
Department
of Radiology, Massachusetts General Hospital and Harvard
Medical School, Boston, MA 02114, United States,
7
Department
of Physics, University of Oslo, Oslo, Norway
We have used Vessel Architectural Imaging to reveal
mechanisms of vascular remodelling in tumor and regions
of peritumoral edema by comparing results from
gliobastomas(GBMs) and metastatic brain tumors(METs). We
found that the relative oxygen saturation level in tumor
and edema regions were significantly higher in GBMs
compared to METs and that vessel calibres of GBMs were
larger than those of METs in tumor. This suggests that
there are marked differences in tumoral and peritumoral
vascular microenvironments in primary and metastatic
brain tumors and that advanced MRI techniques may give
valuable insights into the mechanisms of angiogenesis
and growth in brain tumor patients.
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