Abstract #0069
The Effect of Systemic Chemotherapy on White Matter Tracts Involved with Cognition in Children with NF1-Associated Optic Pathway Gliomas
Peter MK de Blank 1 , Michael J Fisher 2 , Timothy PL Roberts 2 , and Jeffrey I Berman 2
1
UH Case Medical Center, Cleveland, OH,
United States,
2
The
Children's Hospital of Philadelphia, PA, United States
Although chemotherapy has been associated with cognitive
deficits and changes in white matter integrity, the
effect of low-intensity chemotherapy (separate from
surgery and radiation) has not been examined. We
examined diffusion tensor imaging (DTI) in 12
age-matched pairs of children with neurofibromatosis
type 1 and optic pathway glioma with or without exposure
to low-intensity chemotherapy, and without exposure to
surgery or radiation. Subjects exposed to low-intensity
chemotherapy had decreased FA in tracts previously
associated with cognitive deficits. Two subjects with
DTI scans before and after exposure to chemotherapy
showed decrease in FA over 1 year.
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