Abstract #0049
Does vasomotion alter functional connectivity? A multi-modal study using Optical Imaging Spectroscopy and BOLD f MRI
Priya Patel 1 , Aneurin James Kennerley 1 , Luke Boorman 1 , Myles Jones 1 , and Jason Berwick 1
1
Psychology, University of Sheffield,
Sheffield, South Yorks, United Kingdom
Slow cerebral oscillations, 0.1 Hz, termed as
vasomotion, could confound neurovascular coupling within
resting state fMRI BOLD signal, therefore inferring
connectivity changes from BOLD fMRI signal in disease
states problematic. We aim to utilize a systematic
analysis of the BOLD fMRI signal and 2 - dimensional
optical imaging spectroscopy (2D-OIS) data to examine
the magnitude and spatial correlations of fluctuations
in BOLD fMRI signals and hemodynamics following
manipulation of the systemic blood pressure in
anesthetized rodents; this will in part emulate
physiological conditions such as in disease states.
Changing the systemic blood pressure modulated the 0.1Hz
vasomotion signal and we have seen a difference in the
inferred connectivity maps before and after this change.
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