Abstract #0037
MR-Guided Blood-Brain Barrier Disruption by Transcranial Focused Ultrasound: Preclinical Testing on a Trans-Human Skull Pig Model
Yuexi Huang 1 , Ryan Alkins 1 , Michael L. Schwartz 2 , and Kullervo Hynynen 1,3
1
Sunnybrook Research Institute, Toronto, ON,
Canada,
2
Division
of Neurosurgery, Sunnybrook Health Sciences Centre,
Toronto, ON, Canada,
3
Department of Medical
Biophysics, University of Toronto, Toronto, ON, Canada
Magnetic resonance-guided focused ultrasound has been
demonstrated to reversibly disrupt the blood-brain
barrier for targeted drug delivery. Many small and large
animal models have been developed to investigate the
effectiveness and characteristics of BBB disruptions.
However, in translation for a clinical trial, the
treatment protocol needs to be optimized according to
properties of human skulls and capabilities of the
current clinical prototype device. In addition, a
cavitation-based safety mechanism needs to be tested in
vivo for minimizing risks of hemorrhage. In this study,
a BBB disruption protocol was developed in a trans-human
skull pig model with human applications in mind. The
trans-human skull pig model demonstrated the feasibility
and safety of the ExAblate system for BBB disruptions in
preparation for human applications.
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