Abstract #0029
Selective magnetic resonance imaging of magnetic nanoparticles by Acoustically Induced Rotary Saturation (AIRS)
Bo Zhu 1,2 , Thomas Witzel 1 , Shan Jiang 3 , Susie Y. Huang 1 , Bruce R. Rosen 1,4 , and Lawrence L. Wald 1,2
1
Martinos Center for Biomedical Imaging,
Department of Radiology, Massachusetts General Hospital,
Charlestown, MA, United States,
2
Harvard-MIT
Division of Health Sciences Technology, Massachusetts
Institute of Technology, Cambridge, MA, United States,
3
David
H Koch Institute for Integrative Cancer Research,
Department of Chemical Engineering, Massachusetts
Institute of Technology, Cambridge, MA, United States,
4
Department
of Meridian & Acupuncture, Collaborating Center for
Traditional Medicine, East-West Medi, Kyung Hee
University, Seoul, Korea
The manual image interpretation process typically
required to locate magnetic nanoparticle contrast agents
from pre- and post-injection scans often results in
ambiguous identifications. We present a resonant
spin-lock acquisition technique to selectively image
iron oxide contrast agents within an entirely
post-injection paradigm, offering more certain
localization of iron oxide presence for research and
clinical studies. The ability to perform block-design
experiments with the methods rapidly modulatable agent
contrast further enables quantitative statistical
analysis, extending the robustness and flexibility of
iron oxide nanoparticles as an investigative molecular
imaging tool.
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