Abstract #0022
Alterations in Myofiber Architecture in Response to Left Ventricular Pressure Overload are Associated with the Upregulation of Genes Encoding for Cell Adhesion and Matrix Remodeling
Choukri Mekkaoui 1 , Howard H Chen 1 , Yin-Ching Iris Chen 1 , Marcel P Jackowski 2 , William J Kostis 1 , Timothy G Reese 1 , Ronglih Liao 3 , and David E Sosnovik 1
1
Harvard Medical School-Massachusetts General
Hospital, Boston, MA, United States,
2
University
of So Paulo, So Paulo, Brazil,
3
Brigham
and Women's Hospital, Boston, MA, United States
Left ventricular hypertrophy (LVH) in response to
pressure overload is initially adaptive but subsequently
becomes maladaptive. We used diffusion tensor MRI (DTI)
to determine how myofiber orientation changes in
response to LVH in aortic-banded mice. In addition, we
performed gene expression analysis to determine which
gene pathways were associated with these changes. We
show that LVH due to pressure overload is accompanied by
a marked rightward shift in fiber orientation in the
left ventricular free wall and the upregulation of genes
encoding for cell-cell and cell-matrix adhesion.
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