Abstract #0017
Can Nuclear Overhauser Enhancement Mediated Chemical Exchange Saturation Transfer (NOE-CEST) Offer a New Insight in Acute Stroke Diagnosis?
Yee Kai Tee 1 , George WJ Harston 2 , Nicholas Blockley 3 , Robert Frost 3 , Thomas W Okell 3 , Sivarajan Thandeswaran 2 , Fintan Sheerin 4 , Peter Jezzard 3 , James Kennedy 2 , Stephen Payne 5 , and Michael Chappell 5
1
Department of Mechatronics and BioMedical
Engineering, Universiti Tunku Abdul Rahman, KL, KL,
Malaysia,
2
Acute
Stroke Programme, Radcliffe Department of Medicine,
Oxford University, Oxfordshire, United Kingdom,
3
Oxford
Centre of Functional MRI of the Brain, Nuffield
Department of Clinical Neurosciences, Oxford University,
Oxfordshire, United Kingdom,
4
Department
of Neuroradiology, Oxford University Hospitals NHS
Trust, Oxfordshire, United Kingdom,
5
Department
of Engineering Science, Institute of Biomedical
Engineering, Oxford University, Oxfordshire, United
Kingdom
Chemical exchange saturation transfer (CEST) data in
acute stroke patients (within 6 hours of onset) were
acquired to compare nuclear Overhauser enhancement
mediated CEST (NOE-CEST) with apparent diffusion
coefficient (ADC) and pH-weighted imaging using amide
proton transfer (APT). This work is the first
demonstration of NOE-CEST in acute human stroke.
NOE-CEST provides a unique contrast compared to ADC and
pH-weighted imaging in tissue that progresses to
infarction, suggesting that NOE-CEST may offer a new
insight in acute stroke management.
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