Abstract #0012
Modelling the effect of white matter microstructure on gradient echo signal evolution
Benjamin Tendler 1 , Samuel Wharton 1 , and Richard Bowtell 1
1
Sir Peter Mansfield Imaging Centre,
University of Nottingham, Nottingham, Nottinghamshire,
United Kingdom
The evolution of the magnitude and phase of gradient
echo (GE) signals is sensitive to white matter (WM)
microstructure. This effect has been characterised by
using a three-pool model of WM, comprised of axonal,
myelin and external compartments. This work compares the
magnitude and phase signals produced using
triple-exponential and geometric single/multiple-fibre
models, showing that the triple-exponential model can be
improved in the static dephasing regime by adding in
terms which approximately account for frequency
variation in the myelin and external compartments. We
also demonstrate the effects of including a range of
fibre sizes and diffusion in a multiple-fibre model.
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