Abstract #0005
In vivo mapping of myelin g-ratio in the human spinal cord
T. Duval 1 , S. Lvy 1 , N. Stikov 1,2 , A. Mezer 3 , T. Witzel 4 , B. Keil 4 , V. Smith 4 , L. L. Wald 4 , E. Klawiter 4 , and J. Cohen-Adad 1,5
1
Institute of Biomedical Engineering,
Polytechnique Montral, Montral, Qubec, Canada,
2
Montreal
Neuronal Institute, McGill University, Montral, Qubec,
Canada,
3
Edmond and Lily Safra Center for
Brain Sciences (ELSC), The Hebrew University, Jerusalem,
Israel,
4
A.A.
Martinos Center for Biomedical Imaging, Massachusetts
General Hospital, Harvard Medical School, Charlestown,
Massachusetts, United States,
5
Functional
Neuroimaging Unit, CRIUGM, Universit de Montral,
Montral, Qubec, Canada
The myelin g-ratio is the ratio of the inner to the
outer diameter of the myelin sheath. As such, it
provides a measure of the myelin thickness that
complements axon morphology, with high specificity
towards demyelination. We demonstrate for the first time
in vivo mapping of myelin g-ratio in the human spinal
cord using 300 mT/m gradient system. Average g-ratio was
0.74, which is consistent with the reported optimal
g-ratio of 0.70 in from histology work. The proposed
method is feasible in a clinically-acceptable time and
could be useful for assessing demyelination in multiple
sclerosis.
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