Abstract #4793
Metabolism of hyperperfused tissue after stroke reperfusion therapy.
Andrew Bivard 1 , Venkatesh Krishnamurthy 2 , and Mark Parsons 2
1
Medicine, University of Melbourne,
Melbourne, Vic, Australia,
2
University
of Newcastle, NSW, Australia
Hyperperfusion on arterial spin labeling (ASL) has been
associated with improved clinical outcome. We sort to
assess the metabolic profile of patients recovering from
ischemic stroke following successful reperfusion and
penumbra salvage. Magnetic resonance spectroscopy was
performed in 60 patients 24 hours after symptom onset
with voxels were placed in the reperfused tissue that
did not infarct on diffusion imaging and exactly
contralateral. Hyperperfusion and increased glutamate on
MRS in recently reperfused tissue was significantly
related to improved patient outcome on the modified
Rankin disability scale (p<0.001). Increased glutamate
and was a marker of significantly better patient outcome
following stroke.
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