Abstract #4791
Methylene blue treatment delays the progression of ischemic penumbra into infarct
Pavel Rodriguez 1 , Jiang Zhao 2 , Shiliang Huang 2 , Qiang Shen 2 , and Timothy Q. Duong 2
1
Department of Radiology, University of Texas
Health Science Center at San Antonio, San Antonio,
Texas, United States,
2
Research
Imaging Institute, University of Texas Health Science
Center at San Antonio, San Antonio, Texas, United States
Methylene blue (MB) has unique energy enhancing and
antioxidant properties and has recently been shown to
reduce neurobehavioral impairment in animal models of
Parkinson's and Alzheimers Diseases. We recently showed
that MB has significant effect on hemodynamics,
metabolic activity, and evoked responses in vivo using
MRI. The goal of this study was to evaluate the
neuroprotective effect of MB treatment in ischemic
stroke. We tested the hypothesis that MB treatment
delays infarct growth in a permanent stroke in rats.
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