Abstract #4787
Underlying mechanisms of Apparent Diffusion Coefficient changes in the stroke rat brain revealed via diffusion basis spectrum imaging and histological examinations
Yi-Hua Hsu 1 , Chien-Hsiang Huang 1 , Chiao-Chi V. Chen 1 , Yong Wang 2 , Peng Sun 2 , Sheng-Kwei Song 2 , and Chen Chang 1
1
Institute of Biomedical Sciences, Academia
Sinica, Taipei, Taiwan, Taiwan,
2
Department
of Radiology, Washington University School of Medicine,
St. Louis, MO, United States
Evaluating the brain with stroke is challenge because
the progressive ischemic injury confounds MRI
measurements. Diffusion weighted MRI has been shown to
be sensitive in detecting acute ischemic lesions while
losing its sensitivity and specificity to ischemic
injury chronically. To demonstrate the underlying tissue
changes leading to this loss of sensitivity and
specificity of DWI, we employed in vivo diffusion basis
spectrum imaging (DBSI), and post-imaging histology to
assess the tissue structural changes in a stroke rat
model. Results showed that DBSI specifically detects the
ischemia-induced tissue damage and cell
infiltration/proliferation.
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