Abstract #4781
TRACT-BASED QUANTITATIVE ANALYSIS OF MYELIN AND AXONAL REMODELING IN THE UNINJURED MOTOR NETWORK AFTER STROKE
Y.C. Lin 1 , A. Daducci 2 , D.E. Meskaldji 2,3 , J.P. Thiran 2,4 , R. Meuli 4 , G. Krueger 5 , G. Menegaz 1 , and C. Granziera 4
1
Computer Science, University of Verona,
Verona, VR, Italy,
2
Ecole
Polytechnique Fdrale de Lausanne, Lausanne, VD,
Switzerland,
3
MIPLab,
Institute of Bioengeneering, Ecole Polytechnique
Fdrale de Lausanne (EPFL), Lausanne, Switzerland,
4
CHUV,
Lausanne, VD, Switzerland,
5
Siemens
Schweiz AG, Renens, VD, Switzerland
Our group previously applied diffusion spectrum and
magnetization transfer imaging (DSI and MTI) to show
motor connectivity plasticity in the uninjured
hemisphere after stroke. However, our previous studies
focused on average MRI indexes of tract integrity
(generalized fractional anisotropy (GFA) and
magnetization transfer ratio (MTR)). These approaches
offered a global view of tract remodeling but failed in
revealing subtle changes affecting only partially single
motor connections. In this work, we applied track-based
quantitative analysis of GFA and MTR and supported
evidence that this approach provides more detailed
information on axonal plasticity and myelination after
stroke.
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