Abstract #4762
Effect of obstructive sleep apnea on cerebrovascular health in children with sickle cell disease
Junseok Kim 1,2 , Jackie Leung 2 , Indra Narang 3 , Suzan Williams 4 , and Andrea Kassner 1,2
1
Medical Imaging, University of Toronto,
Toronto, Ontario, Canada,
2
Physiology
and Experimental Medicine, The Hospital for Sick
Children, Toronto, Ontario, Canada,
3
Respiratory
Medicine, The Hospital for Sick Children, Toronto,
Ontario, Canada,
4
Haematology,
The Hospital for Sick Children, Toronto, Ontario, Canada
Previous work on the pediatric sickle cell disease (SCD)
population has demonstrated that cerebrovascular
reactivity (CVR), a measure of vascular health, was
globally reduced compared to healthy controls. In
addition, a high percentage of SCD patients suffer from
obstructive sleep apnea (OSA). It is currently unknown
if the presence of OSA in SCD further impairs vascular
health. We hypothesized that CVR is globally reduced in
SCD patients with OSA compared to those without. The
results showed that CVR in the SCD patients with OSA was
significantly lower than those without OSA, thus placing
them at greater risk for serious vasculopathies.
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