Abstract #4755
Cerebral Vascular Reactivity Assessment Using the SR-T 1 Method in Normal and MCAO Rat Brain
Xiao Wang 1 , Xiao-Hong Zhu 1 , Afshin A Divani 2 , and Wei Chen 1
1
Center for Magnetic Resonance Research,
Department of Radiology, University of Minnesota Medical
School, Minneapolis, Minnesota, United States,
2
Neurology,
University of Minnesota, Minnesota, United States
Cerebral vascular reactivity (CVR) is an important
physiologic property of assessing brain arteries
response to vasoactive challenge and it is of great
value of studying many cerebrovascular diseases, such as
arterial stenosis, ischemic stroke and hypertension. CVR
could be evaluated by positron emission tomography
(PET), single-photon emission computed tomography
(SPECT), transcranail Doppler (TCD) ultrasonography as
well as magnetic resonance imaging (MRI) approaches,
such as blood-oxygen-level dependent (BOLD) response,
arterial spin labeling (ASL) based cerebral blood flow
(CBF) calculation. In the present study, we demonstrate
that the saturation-recover T1 (SR-T1) imaging method is
sensitive and reliable to evaluate CVR by comparing it
with the CASL based CBF method. Data show that the
spatial pattern of CVR images generated with these two
techniques is very similar in both normal and MCAO rat
brain. Moreover, there is an excellent agreement of
percentage CVR change imaged with these two techniques
although their absolute scales are different. Therefore,
the SR-T1 method provides a simple and reliable way of
evaluating CVR in addition to measure parametric tissue
property of T1/R1, CBF change and BOLD simultaneously.
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