Abstract #4742
Focal thalamic degeneration is involved in PC/PCC dIsconnection and cognitive deficits of early Alzheimer's disease
Paolo Vitali 1,2 , Fulvia Palesi 3,4 , Gloria Castellazzi 4,5 , Carol Di Perri 2 , Stefano Bastianello 2,6 , Elena Sinforiani 7 , and Egidio D'Angelo 4,8
1
Brain MRI 3T Mondino Research Center, C.
Mondino National Neurological Institute, Pavia, PV,
Italy,
2
Department
of Brain and Behavioural Sciences, University of Pavia,
Pavia, PV, Italy,
3
Department
of Physics, University of Pavia, PV, Italy,
4
Brain
Connectivity Center, National Neurological Institute C.
Mondino, Pavia, PV, Italy,
5
Department
of Industrial and Information Engineering, University of
Pavia, Pavia, PV, Italy,
6
Neuroradiology,
National Neurological Institute C. Mondino, Pavia, PV,
Italy,
7
Neurology,
National Neurological Institute C. Mondino, Pavia, PV,
Italy,
8
Department
of Brain and Behavioural Sciences, University of Pavia,
Pavia, PV, Italy, University of Pavia, Pavia, PV, Italy
The aim of this study was to test whether thalamic,
other than hippocampal, degeneration is significant in
early phases of Alzheimer's disease, and if it can also
drive PC/PCC dysconnection and early cognitive
deficits.In this study, both voxel-wise and VOI analysis
demonstrated in AD and MCI a significant diffuse
macrostructural (atrophy) and microstructural (^MD)
degeneration of hippocampi and hippocampal-PC/PCC
tracts, but only focal mild degeneration of thalami and
thalamic-PC/PCC tracts. However, the most significant
neuropsychological correlation in AD and was found for
the right thalamic-PC/PCC tract, and degeneration of
left PC/PCC correlated with atrophy of the thalamic-PC/PCC
tract. As a whole, these results suggest that, although
hippocampi and hippocampal-PC/PCC tracts are more
significantly degenerated, focal thalamic degeneration
could also drive PC/PCC disconnection and cognitive
deficits in early phases of Alzheimer's disease.
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