Abstract #4725
Testing models of neurodegenerative spread via regional atrophy and its slope
Ashish Raj 1 and Eve LoCastro 2
1
Radiology and Neuroscience, Weill Cornell
Medical College, New Nork, NY, United States,
2
Radiology,
Weill Cornell Medical College, New York, NY, United
States
Atrophy progression in Alzheimers Disease is highly
stereotyped, starting from medial temporal origins, to
adjoining temporal and parietal cortices, and finally to
frontal cortex. The purpose of this study is to
quantitatively compare 3 popular models of spread:
exponential, sigmoid and network-diffusion, by applying
them to MRI-derived volumetric data from the public ADNI
database. We test how well these models capture the
relationship between baseline and rate of change of
atrophy. We find that the network-diffusion models
slope prediction matched measured atrophy slope more
accurately than competing models.
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