Abstract #4720
Diffusion Tensor Imaging Studies Support Pre-symptomatic Degeneration of Selective Axonal Fibers in a Mouse Model of Amyotrophic Lateral Sclerosis (Lou Gehrigs disease).
Rodolfo Gatto 1 , Weiguo Li 2 , Ehsan Tavassoli 1 , Andrea Buenaventura 1 , William Hendrickson 3 , Gerardo Morfini 1 , and Richard Magin 2
1
Department of Anatomy and Cell Biology,
University of Illinois at Chicago, Chicago, Illinois,
United States,
2
Department
of Bioengineering, University of Illinois at Chicago,
Chicago, Illinois, United States,
3
Research
Resource Center, University of Illinois at Chicago,
Chicago, Illinois, United States
Amyotrophic lateral Sclerosis (ALS) is characterized by
progressive degeneration and eventual death of motor
neurons in the spinal cord. Among several mutant SOD1
mouse models generated, G93A-SOD1 represent the
best-characterized one. The remarkable correspondence in
clinical phenotype observed between G93A-SOD1 mice and
human ALS made this model a benchmark for pre-clinical
screening of ALS therapies. As a step towards this end,
we performed correlative diffusion tensor imaging (DTI)
and histological studies in white (WM) and grey (GM)
matter of spinal cords obtained from pre-symptomatic
G93A-SOD1 mice and wild-type (control, WT-SDO1) mice
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