Abstract #4713
Cortico-striatal-thalamic network functional connectivity in hemiparkinsonism
Francesca Caso 1 , Federica Agosta 1 , Iva Stankovic 2 , Alberto Inuggi 1 , Igor Petrovic 2 , Marina Svetel 2 , Vladimir S Kostic 2 , and Massimo Filippi 1
1
Neuroimaging Research Unit, Institute of
Experimental Neurology, San Raffaele Scientific
Institute, Vita-Salute San Raffaele University, Milan,
MI, Italy,
2
Clinic of Neurology, Faculty of
Medicine, University of Belgrade, Belgrade, BG,
Yugoslavia
Cortico-striatal-thalamic functional connectivity (FC)
was assessed in chronically treated (t-PD) and
drug-nave (n-PD) hemiparkinsonian patients.. N-PD
patients experienced an increased basal ganglia
reciprocal connectivity while the affected caudate
nucleus and thalamus were hypoconnected with the
ispilateral fronto-insular cortices. The enhanced
subcortical FC was normalized, or inverted into
hypoconnectivity, in t-PD patients, who also exhibited
an increased FC of the striatal and thalamic regions
with the sensorimotor and association posterior
cortices. FC changes occur in early hemiparkinsonian
patients, antecede the onset of motor symptoms on the
opposite body side, and are modulated by levodopa
possibly through an increased thalamic outflow.
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