Abstract #4706
Longitudinal DTI Study in Parkinson's Disease
Ling Ling Chan 1,2 , Helmut Rumpel 1 , Kia Min Ng 2 , Chooi Sum Yeoh 1 , and Eng King Tan 2,3
1
Singapore General Hospital, Singapore,
Singapore,
2
Duke-NUS
Graduate Medical School, Singapore, Singapore,
3
National
Neuroscience Institute, Singapore
This longitudinal case control DTI study evaluated the
rate of change in FA and ADC in Parkinsons disease over
a 5 year period. We found an increased FA and ADC in the
basal ganglia and substantia nigra. There was a
significant difference in the rate of change in the DTI
parametrics in the putamen, thalamus, substantia nigra
and frontal white matter between PD and controls. The
increased FA of gray nuclei in PD over time was
unexpected and possibly related to iron deposition. The
rate of DTI changes over time may be useful as potential
imaging markers of disease progression.
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