Abstract #4692
Human post-mortem brain phantom as a standardization model for multicentre MRI studies
Amgad Droby 1 , Adriane Grger 1 , Isabella Spiwoks-Becker 2 , Anne Schnzer 3 , Till Acker 3 , Frauke Zipp 1 , and Ralf Deichmann 4
1
Neurology department-Neuroimaging center
(NIC), Johannes Gutenberg university hospital, Mainz,
Deutschland, Germany,
2
Institute
of microanatomy and neurobiology, Johannes Gutenberg
university hospital, Mainz, Deutschland, Germany,
3
Institute
for neuropathology, Justus Liebig University, Giessen,
Deutschland, Germany,
4
Brain
Imaging Center (BIC), Goethe University, Frankfurt am
Main, Deutschland, Germany
Multi-centre MRI studies are essential for enrolling
large and diverse patient cohorts in the study of
neurological diseases. Therefore, a multi-centre MRI
standardization tool that mimics the in-vivo human brain
is needed. Here, we provide evidence that a human
post-mortem brain is a valid model for the
standardization of multi-centre MRI studies. Using T1
mapping, T2, MTR and PD, the relaxation times of this
model were found to be stable over the time course.
Moreover, such a model can provide volumetric measures
of GM and WM, which could also be used for intra- as
well as inter-site comparisons.
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