Abstract #4689
Extremely slow water diffusion in rodent brain as a intracellular biomarker for aging
SHU-JUAN FAN 1,2 , Peng CAO 1,2 , Wenwen A. Han 1,2 , and Ed Wu 1,2
1
Laboratory of Biomedical Imaging and Signal
Processing, The University of Hong Kong, Hong Kong, Hong
Kong, SAR, China,
2
Department
of Electrical and Electronic Engineering, The University
of Hong Kong, Hong Kong, Hong Kong, SAR, China
Extremely slow water diffusion at ultrahigh b values in
brain is thought to be related to restricted water
diffusion in the nerve fibers and transmembrane water
flux. With diffusion-weighted MRS, this study
demonstrated a decrease of slow water ADC and increase
of its fraction with aging, and the gradual development
of the slow-diffusion water pool during postnatal
development. These results were potentially related to
the degenerative changes in nerve fiber during aging and
the development of axonal membranes and myelin sheath
during early life, supporting slow water diffusion as an
intracellular biomarker for assessing aging-related
structural brain changes.
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