Abstract #4683
Diffusion kurtosis metrics as biomarkers of microstructural development: a comparative study of a group of children and a group of adults
Farida A Grinberg 1,2 , Ivan I Maximov 1 , Ezequiel Farrher 1 , Irene Neuner 1,3 , Laura Amort 1,4 , Heike Thnneen 1,5 , Kerstin Konrad 6,7 , and N. Jon Shah 1,8
1
INM-4, Forschungszentrum Juelich, Juelich,
Germany,
2
Department
of Neurology, RWTH Aachen University, Aachen, Germany,
3
Department
of Psychiatry, Psychotherapy and Psychosomatics, RWTH
Aachen University, Germany,
4
Department
of Psychiatry, Psychotherapy and Psychosomatics, RWTH
Aachen University, Aachen, Germany,
5
Department
of Child and Adolescent Psychiatry and Psychotherapy,
RWTH Aachen University, Germany,
6
Department
of Child and Adolescent Psychiatry and Psychotherapy,
RWTH Aachen University, Aachen, Germany,
7
Institute
of Neuroscience and Medicine 3, Forschungszentrum,
Germany,
8
Department
of Neurology, RWTH Aachen University, Germany
Recently, diffusion kurtosis imaging (DKI) has become
interesting as an efficient method for characterising
non-Gaussian water diffusion in brain tissue. In this
work, we used DKI to evaluate and compare water
diffusion properties in the whole brain and in
anatomically defined regions in a group of children and
in a group of adults. An intergroup comparison using
TBSS and averaged atlas-based regional data analysis
shows that DKI metrics are significantly more sensitive
to age related microstructural changes than conventional
DTI.
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