Abstract #4653
Hemispherical asymmetry contributes to preserved language abilities in alcohol dependents: A combined 1H MRS and VBM approach
Deepika Bagga 1 , Shilpi Modi 1 , Prabhjot Kaur 1 , Mohan lal Garg 2 , Debajyoti Bhattacharya 3 , Subash Khushu 1 , and Namita Singh 1
1
NMR Research centre, INMAS, Delhi, delhi,
India,
2
Department
of Biophysics, Panjab University, Chandigarh, Punjab,
India,
3
Department
of psychiatry, Base Hospital, Delhi, delhi, India
Language abilities are primarily left lateralized and
relatively preserved in alcohol dependents. A recent
fMRI study at our centre has also suggested a probable
involvement of left parieto-temporal network in
maintaining language functions. Thus, to assess the
metabolic and structural basis of preserved language
abilities, proton in vivo MRS study on parietal and
temporal lobe bilaterally and whole brain VBM study were
performed on alcohol dependent subjects and healthy
controls. The preserved metabolite ratios and intact
gray and white matter volumes in left hemisphere as
compared to right hemisphere might contribute to
preserved language abilities in alcohol dependent
subjects.
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