Abstract #4573
Decrease in intracranial vascular compliance is associated with cerebral hypoperfusion
Lirong Yan 1 , Collin Liu 2 , Robert Smith 1 , John Ringman 1 , and Danny JJ Wang 1
1
University of California Los Angeles, Los
Angeles, CA, United States,
2
University
of Southern California, CA, United States
Both arterial stiffening (or reduced vascular
compliance) and cerebral hypoperfusion have been found
to be associated with aging and dementia. The purpose of
this study is to investigate the relationship between
intracranial vascular compliance and perfusion measured
using a novel dynamic arterial-spin labeling (ASL)
technique and pseudo-continuous ASL 3D GRASE MRI
respectively. The results show that vascular compliance
and perfusion are correlated with each other and both
decrease with aging and vascular risks. This study
supports arterial stiffening and cerebral hypoperfusion
as markers of vascular risks and dementia.
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