Abstract #4521
Independent component analysis with ball-stick model tractography to solve an intra-voxel crossing fiber problem in clinical DTI data
Jeong-Won Jeong 1,2
1
Pediatrics and Neurology, Wayne State
University, Detroit, Michigan, United States,
2
PET
center, Children's Hospital of Michigan, Detroit,
Michigan, United States
The present study investigates whether independent
component analysis with ball-stick model (ICA+BSM)
analysis can estimate accurate orientation of multiple
fiber bundles in clinical DTI. Simultaion studies
assessing the absolute errors for two and three fibers
per voxel demonsrated that ICA+BSM provides promising
accuracy (median value of error angle = 4.1 and 10.4
for two and three fiber crossing, respectively) even at
b-value =1000 s/mm
2
and
12 encoding gradients. A preliminary human study
suggests these errors may be marginal to isolate three
crossing pathways, copus callosum, arcuate fasciculus,
and cortico-spinal tracts in the lateral regions of
central gyrus/sulcus.
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