Abstract #4514
Quantification of voxel-wise total tract density: addressing the problems associated with track-count mapping
Fernando Calamante 1,2 , Robert Elton Smith 1 , J-Donald Tournier 1,3 , David Raffelt 1 , and Alan Connelly 1,2
1
The Florey Institute of Neuroscience and
Mental Health, Melbourne, Victoria, Australia,
2
Department
of Medicine, Austin Health and Northern Health,
University of Melbourne, Melbourne, Victoria, Australia,
3
Centre
for the Developing Brain, King's College London, London,
United Kingdom
A biological parameter that would be valuable to draw
from a DWI experiment is the local white matter axonal
density. It has been suggested that track-density
imaging (TDI) could provide such a measure; however,
this has been the subject of controversy. The
post-processing method of SIFT was recently introduced
to minimise tractography biases. Importantly, the TDI
intensity following SIFT ideally corresponds to the DC
term of the FOD spherical harmonic expansion. We
characterise the TDI reproducibility with and without
SIFT pre-processing, as well as the reproducibility of
DC maps, to determine the most appropriate method for
quantifying voxel-wise fibre densities.
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