Abstract #4468
CSF contamination contributes to apparent microstructural alterations in amnestic Mild Cognitive Impairment
Rok Berlot 1,2 , Claudia Metzler-Baddeley 3 , Derek K Jones 3 , and Michael J O'Sullivan 1
1
Department of Clinical Neuroscience,
Institute of Psychiatry, King's College London, London,
United Kingdom,
2
Department
of Neurology, University Medical Centre Ljubljana,
Ljubljana, Slovenia,
3
Cardiff
University Brain Research Imaging Centre (CUBRIC),
School of Psychology, and the Neuroscience and Mental
Health Research Institute, Cardiff University, Cardiff,
United Kingdom
Partial volume effects due to cerebrospinal-fluid
contamination (CSFC) lead to artefacts in diffusion MRI
studies in populations prone to atrophy. We explored the
influence of CSFC on apparent microstructural
differences in amnestic mild cognitive impairment (MCI).
A post-acquisition method of Free Water Elimination was
used to correct for CSFC. Comparisons between controls
and MCI were performed at several spatial levels in
uncorrected and corrected data. CSFC shifted the pattern
of involvement of individual temporal association
tracts. Tract-based spatial statistics were robust to
CSFC with notable localised exceptions. A proportion of
group difference in mean histogram metrics was driven by
CSFC.
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