Abstract #4455
Probing white matter microstructure at high spatial resolution combining CHARMED protocol optimization and a high performance gradient set
Matteo Bastiani 1 , Silvia De Santis 2,3 , Derek Jones 2,3 , Yaniv Assaf 4 , and Alard Roebroeck 1
1
Department of Cognitive Neuroscience,
Maastricht University, Maastricht, Limburg, Netherlands,
2
CUBRIC,
School of Psychology, Cardiff University, Cardiff,
United Kingdom,
3
Neuroscience
and Mental Health Research Institute, Cardiff
University, Cardiff, United Kingdom,
4
Department
of Neurobiology, The George S. Wise Faculty of Life
Sciences, Tel Aviv University, Tel Aviv, Israel
The composite hindered and restricted model of diffusion
(CHARMED) typically requires multiple acquisitions with
high b-values and high angular resolution, both of which
are difficult to obtain with clinical MRI systems. The
purpose of this study is to investigate the feasibility
of probing white matter microstructure at high spatial
resolution in vivo at 3T, combining protocol
optimization and a high amplitude, high slew-rate
gradient set. Different levels of trade-off between
resolution, SNR and diffusion contrast are compared and
the results are further compared to a benchmark dataset
obtained from the Human Connectome Project (HCP).
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