Abstract #4453
Rotating Field Gradient (RFG) Diffusion MRI for Mapping 3D Orientation Distribution Functions (ODFs) in the Human Brain
Alexandru V Avram 1 , Joelle E Sarlls 2 , Peter J Basser 1 , and Evren Ozarslan 3
1
Section on Tissue Biophysics and
Biomimetics, NICHD, National Institutes of Health,
Bethesda, MD, United States,
2
NINDS,
National Institutes of Health, Bethesda, MD, United
States,
3
Department
of Radiology, Brigham and Women's Hospital, Harvard
Medical School, Boston, MA, United States
Conventional methods for mapping 3D diffusion
orientation distribution functions (dODFs) of neuronal
microstructure require long acquisitions and are prone
to quantitation errors due to subject motion. In this
study we describe a method for directly measuring in
vivo 3D dODFs with a novel technique called Rotating
Field Gradient (RFG) diffusion MRI, which applies
sinusoidal diffusion gradients in arbitrarily oriented
planes to directly sample the dODFs along the axis of
rotation. RFG dMRI represents a fast, direct and
model-free method for mapping 3D ODFs that could
represent a powerful alternative to conventional
pulse-field gradient diffusion MRI techniques.
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