Abstract #4449
Accelerated human cardiac diffusion tensor imaging using simultaneous multi-slice imaging
Angus Z. Lau 1,2 , Elizabeth M. Tunnicliffe 1 , Robert Frost 3 , Peter J. Koopmans 3 , Damian J. Tyler 1,2 , and Matthew D. Robson 1
1
Department of Cardiovascular Medicine,
University of Oxford, Oxford, United Kingdom,
2
Department
of Physiology, Anatomy, and Genetics, University of
Oxford, Oxford, United Kingdom,
3
FMRIB
Centre, University of Oxford, Oxford, United Kingdom
Remodeling of cardiac fibre structure contributes to
impaired cardiac function, and is implicated in the
development of cardiac arrhythmias and sudden cardiac
death. Diffusion tensor imaging (DTI) allows
non-invasive detection of microstructure in vivo, but
low SNR leads to long scan times, limiting the patient
population which can benefit from such exams. In this
abstract, we investigate the feasibility of using
simultaneous multi-slice (SMS) excitation to accelerate
human DTI of the heart. We demonstrate three-fold scan
time reduction of cardiac diffusion measurements, and we
anticipate this development will make it practical to
incorporate DTI within a comprehensive clinical exam.
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