Abstract #4434
In Vivo Observation of Time-Dependent Diffusion in White Matter in Humans
Lauren Burcaw 1 , Jelle Veraart 2 , Dmitry S Novikov 1 , and Els Fieremans 1
1
New York University School of Medicine,
Bernard and Irene Schwartz Center for Biomedical
Imaging, Department of Radiology, New York, NY, United
States,
2
Vision
Lab, Department of Physics, University of Antwerp,
Antwerp, Belgium
We report on time-dependent diffusion in white We report
on time-dependent diffusion in white matter as measured
on three normal human volunteers over diffusion times
ranging from 26 to 400 ms. A decrease in axial
diffusivity with time is found indicating the presence
of restrictions to diffusion along the axonal direction.
We also note a decrease in radial diffusion with respect
to time, however this decrease is less pronounced. Our
results imply that axial and possibly radial
time-dependent diffusion may be observable using
clinical systems.
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