Abstract #4428
Methods for comparing fiber orientation distribution (FOD) functions based on histology and diffusion MRI
Yurui Gao 1 , Ann Choe 2 , Iwona Stepniewskwa 3 , Xia Li 2 , and Adam W Anderson 4
1
VUIIS, Vanderbilt University, Nashville,
Tennessee, United States,
2
VUIIS,
Vanderbilt University, TN, United States,
3
Psychology,
Vanderbilt University, TN, United States,
4
BME,
Vanderbilt University, TN, United States
In previous studies, we validated
DTI-tractography-derived connectivity by comparing with
the histological ground truth. Because DTI fiber
orientation estimation is the basis of tractography,
juxtaposing the DTI fiber orientation distribution
(dFOD) and histological FOD (hFOD) is critical to
validation studies. However, obtaining the 3D hFOD is
challenging. This study introduces 1) two methods to
extract the hFOD from z-stack micrographs and 2) the
procedure to compare dFOD with hFOD functions.
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